ERBB3 anticorps (C-Term)

N° du produit ABIN126793

Détail du produit anti-ERBB3 anticorps

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Épitope: C-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERBB3 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody specifically recognizes the C-terminus of erbB3 at 185 kDa.

Attributs du produit: Synonyms: ERBB-3, c-erbB-3, HER-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cellsurface receptor HER3, Proto-oncogene-like protein c-ErbB-3

Purification: Subsequent Thiophilic Adsorption and Size Exclusion Chromatography

Ingrédients: incl. positive Control

Immunogène: Synthetic petide conjugated to KLH.

Clone: 11A4

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 0.5 μg/mL for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubationbuffer.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1 mL H2O (15 min, RT)

Buffer: 1 mLPBS, 0.09 % Sodium Azide, PEG and Sucrose

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C/-80 °C

Stockage commentaire: Store lyophilized (preferably in a desiccator) at -20 °C and reconstituted (aliquote andfreeze in liquid nitrogen) at -80 °C. Avoid repeated freezing and thawing. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 4 °C up to 3 months.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur ERBB3

Antigène: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Autre désignation: ERBB3 / HER3 (ERBB3 Produits)

Synonymes: anticorps ErbB-3, anticorps HER3, anticorps LCCS2, anticorps MDA-BF-1, anticorps c-erbB-3, anticorps c-erbB3, anticorps erbB3-S, anticorps p180-ErbB3, anticorps p45-sErbB3, anticorps p85-sErbB3, anticorps ERBB3, anticorps C76256, anticorps Erbb-3, anticorps Erbb3r, anticorps Her3, anticorps nuc-ErbB3, anticorps erb-b2 receptor tyrosine kinase 3, anticorps v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), anticorps ERBB3, anticorps Erbb3

Sujet: ErbB3 is a member of the EGFR/erbB receptor tyrosine kinase family. ErbB3 lacks intrinsic kinase activity due to an amino acid substitution within the ATP binding site. Upon heterodimerization with the other erbB family members, erbB3 becomes phosphorylated at multiple tyrosine residues that represent docking sites for downstream signaling proteins, e.g. PI3K, grb7 and shc. The erbB3 cytoplasmic domain contains 6 docking sites for PI3K. Thus, erbB3 is a potent activator of the PI3K/PKB signaling pathway.Synonyms: ERBB-3, HER-3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3

Poids moléculaire: 185 kDa

ID gène: 2065

UniProt: P21860

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway