Calreticulin anticorps

N° du produit ABIN126927

Cet anticorps anti-Calreticulin Monoclonal Souris (Clone S75) (ABIN126927) détecte spécifiquement Calreticulin dans WB, IP et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Singe.

Aperçu rapide pour Calreticulin anticorps (ABIN126927)

Antigène: Calreticulin (CALR)

Reactivité: Humain, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Calreticulin est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: S75

Détail du produit anti-Calreticulin anticorps

Specificité: The antibody recognizes a 63 kDa Calreticulin on SDS-PAGE Immunoblots.

Attributs du produit: Synonyms: CRP55, Calregulin, HACBP, ERp60, grp60, CALR, CRTC

Purification: Affinity Chromatography on Protein A

Immunogène: Calreticulin-maltose binding fusion protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: PBS containing 1 mg/mL BSA, 0.02 % Thimerosal and 50 % Glycerol

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the antibody at -20 °C or For long term storage, aliquot and refreeze at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Calreticulin

Antigène: Calreticulin (CALR)

Autre désignation: Calreticulin

Sujet: Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus. Calreticulin has also been detected in the nucleus and nuclear envelop. Recent studies suggest that this soluble ER protein has a multifunctional role as it appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. Studies also suggest its involvement in certain autoimmune diseases. Consistence with its multiple functions the calreticulin molecule appears to have a zonal character. The protein has both high and low affinity calcium binding sites.Synonyms: CALR, CRP55, CRTC, Calregulin, ERp60, HACBP, grp60

ID gène: 811

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response