FOXO4 anticorps (pSer193)

N° du produit ABIN127070

Détail du produit anti-FOXO4 anticorps

Antigène: FOXO4 (Forkhead Box O4 (FOXO4))

Épitope: pSer193

Reactivité: Humain, Hamster

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXO4 est non-conjugé

Application: Western Blotting (WB)

Specificité: Phospho-AFX (Ser193) antibody detects only the phosphorylated Ser193 of AFX and does not react with nonphosphorylated AFX.

Purification: Peptide affinity chromatography

Information d'application

Indications d'application: The antibody can be used for Western blotting (1-2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 30 % glycerol, 0.5 % BSA, and 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C. For long term storage freeze at -70 °C.

Détails sur FOXO4

Antigène: FOXO4 (Forkhead Box O4 (FOXO4))

Autre désignation: FOXO4 / AFX1 / MLLT7 (FOXO4 Produits)

Synonymes: anticorps FOXO4, anticorps foxo4, anticorps AFX, anticorps AFX1, anticorps MLLT7, anticorps Afxh, anticorps Mllt7, anticorps afx, anticorps RGD1561201, anticorps forkhead box O4, anticorps forkhead box O4 L homeolog, anticorps FOXO4, anticorps foxo4.L, anticorps Foxo4

Sujet: The forkhead family of transcription factors is involved in tumorigenesis in rhabdomyosarcoma and acute leukemias. Within the family, three members (FKHR, AFX, AND FKHRL1) have sequence similarity to the nematode homolog Daf 16, recently shown to mediate signaling via a pathway involving IGFR1, P13-K and Akt. There are three potential Akt phosphorylation sites on the FKHR proteins. One site, FKHR Ser256 is found in the Forkhead domain and the other two are outside this domain. Recent studies show that phosphorylation of FKHR family members by Akt promotes cell survival. Phosphorylation regulates FKHR nuclear translocation and target gene transcription. Insulin also stimulates FKHR phosphorylation at Ser253.Synonyms: Fork head domain transcription factor AFX1, Forkhead box protein O4

ID gène: 4303

NCBI Accession: NP_001164402

UniProt: P98177

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation