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KIT anticorps (Biotin)

KIT Reactivité: Humain, Boeuf (Vache), Non-Human Primate FACS, IP, IHC (fro), ICC Hôte: Souris Monoclonal 104D2 Biotin
N° du produit ABIN1302740
  • Antigène Voir toutes KIT Anticorps
    KIT (Mast/stem Cell Growth Factor Receptor (KIT))
    Reactivité
    • 674
    • 241
    • 66
    • 29
    • 28
    • 27
    • 17
    • 13
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Humain, Boeuf (Vache), Non-Human Primate
    Hôte
    • 602
    • 106
    • 48
    • 2
    • 1
    Souris
    Clonalité
    • 594
    • 165
    • 1
    Monoclonal
    Conjugué
    • 231
    • 80
    • 78
    • 77
    • 62
    • 60
    • 14
    • 14
    • 13
    • 13
    • 13
    • 13
    • 11
    • 10
    • 10
    • 10
    • 10
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KIT est conjugé à/à la Biotin
    Application
    • 432
    • 394
    • 298
    • 147
    • 91
    • 91
    • 68
    • 50
    • 46
    • 45
    • 33
    • 24
    • 10
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Specificité
    The mouse monoclonal antibody 104D2 detects extracellular part of CD117 / c-Kit protooncogen.
    Réactivité croisée (Details)
    Human, Non-Human Primates, Bovine
    Purification
    Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
    Immunogène
    MOLM-1 megakaryocytic cells
    Clone
    104D2
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product KIT Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1 μg/mL.
    Commentaires

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Stevenson, McGlynn, Hodge, McLinden, George, Davies, Shiels: "Isolation, characterization, and differentiation of thy1.1-sorted pancreatic adult progenitor cell populations." dans: Stem cells and development, Vol. 18, Issue 10, pp. 1389-98, (2009) (PubMed).

    Wihlidal, Varga, Pfeilstöcker, Karlic: "Expression and functional significance of osteocalcin splicing in disease progression of hematological malignancies." dans: Leukemia research, Vol. 30, Issue 10, pp. 1241-8, (2006) (PubMed).

    Blair, Sutherland: "Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117)." dans: Experimental hematology, Vol. 28, Issue 6, pp. 660-71, (2000) (PubMed).

    Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." dans: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, (2000) (PubMed).

    Broudy, Lin, Liles, Corey, OLaughlin, Mou, Linnekin: "Signaling via Src family kinases is required for normal internalization of the receptor c-Kit." dans: Blood, Vol. 94, Issue 6, pp. 1979-86, (1999) (PubMed).

    Broudy, Lin, Bühring, Komatsu, Kavanagh: "Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer." dans: Blood, Vol. 91, Issue 3, pp. 898-906, (1998) (PubMed).

    Rappold, Ziegler, Köhler, Marchetto, Rosnet, Birnbaum, Simmons, Zannettino, Hill, Neu, Knapp, Alitalo, Alitalo, Ullrich, Kanz, Bühring: "Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase." dans: Blood, Vol. 90, Issue 1, pp. 111-25, (1997) (PubMed).

  • Antigène
    KIT (Mast/stem Cell Growth Factor Receptor (KIT))
    Autre désignation
    CD117 (KIT Produits)
    Synonymes
    anticorps C-Kit, anticorps CD117, anticorps PBT, anticorps SCFR, anticorps Bs, anticorps Fdc, anticorps Gsfsco1, anticorps Gsfsco5, anticorps Gsfsow3, anticorps SCO1, anticorps SCO5, anticorps SOW3, anticorps Ssm, anticorps Tr-kit, anticorps W, anticorps c-KIT, anticorps c-kit, anticorps MGF, anticorps KIT, anticorps C-KIT, anticorps kit, anticorps receptor, anticorps sparse, anticorps Xkl-1, anticorps kit-a, anticorps kit-b, anticorps kl1-A, anticorps krk1, anticorps pbt, anticorps scfr, anticorps KIT proto-oncogene receptor tyrosine kinase, anticorps v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a, anticorps KIT proto-oncogene receptor tyrosine kinase S homeolog, anticorps KIT, anticorps Kit, anticorps kita, anticorps kit, anticorps kit.S
    Sujet
    KIT proto-oncogene, receptor tyrosine kinase,CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.,c-Kit, PBT, SCFR
    ID gène
    3815
    UniProt
    P10721
    Pathways
    Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
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