CD44 anticorps

N° du produit ABIN135065

L’anticorps Rat Monoclonal anti-CD44 a été validé pour FACS. Il convient pour détecter CD44 dans des échantillons de Souris. Il y a 3+ publications disponibles.

Aperçu rapide pour CD44 anticorps (ABIN135065)

Antigène: CD44

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD44 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: KM201

Détail du produit anti-CD44 anticorps

Specificité: Mouse CD44 (all isoforms), Mr 80-95 kDa

Attributs du produit: Rat Anti-Mouse CD44-UNLB

Purification: Purified

Immunogène: (C57BL/6 x DBA/2)F1 mouse bone marrow-derived stromal clone BMS2

Isotype: IgG1

Information d'application

Indications d'application:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , IHC-PS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , WB - Reported in literature , Block - Reported in literature , Adhesion - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 2 g/106 cells PE, APC, and SPRD conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Commentaires:

cell adhesion and homing

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Références pour anticorps anti-CD44 (ABIN135065)

Rux, Song, Swinehart, Pineault, Schlientz, Trulik, Goldstein, Kozloff, Lucas, Wellik: "Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells." dans: Developmental cell, Vol. 39, Issue 6, pp. 653-666, (2017) (PubMed).

Goldman, Majumder, Dhawan, Ravi, Goldman, Kohandel, Majumder, Sengupta: "Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition." dans: Nature communications, Vol. 6, pp. 6139, (2016) (PubMed).

Sánchez, Hill, Love, Soslow, Craig, Austin, Brown, Czirok, Camenisch, Barnett: "The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior." dans: Developmental biology, Vol. 358, Issue 2, pp. 331-43, (2011) (PubMed).

Détails sur CD44

Antigène: CD44

Autre désignation: CD44

Sujet: CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte Cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling