CD80 anticorps

N° du produit ABIN135268

Cet anticorps Rat Monoclonal détecte spécifiquement CD80 dans FACS. Il présente une réactivité envers Souris.

Aperçu rapide pour CD80 anticorps (ABIN135268)

Antigène: CD80

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD80 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 1G10

Détail du produit anti-CD80 anticorps

Specificité: Mouse CD80, Mr 52-55 kDa

Attributs du produit: Rat Anti-Mouse CD80-UNLB

Purification: Purified

Immunogène: Activated 5C2 cells

Isotype: IgG2a

Information d'application

Indications d'application:

• Applications: FC - Quality tested , IP - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE, APC, and SPRD conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Commentaires:

In vivo and in vitro blocking of ligand binding

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur CD80

Antigène: CD80

Autre désignation: CD80

Sujet: CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours post-activation. The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex.

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints