COPS2 anticorps

N° du produit ABIN1386249

Cet anticorps anti-COPS2 Polyclonal Lapin (ABIN1386249) détecte spécifiquement COPS2 dans WB, IF (p) et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour COPS2 anticorps (ABIN1386249)

Antigène: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-COPS2 anticorps

Fonction: COPS2 Polyclonal Antibody

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human COPS2/TRIP15

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000), IHC-P(1:200-400), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur COPS2

Antigène: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Autre désignation: COPS2

Sujet:

Synonyms: ALIEN, Alien homolog, COP 9, COP9, COP9 constitutive photomorphogenic homolog subunit 2, COP9 signalosome complex subunit 2, COPS 2, Cops2, CSN2, CSN2_HUMAN, JAB1 containing signalosome subunit 2, JAB1-containing signalosome subunit 2, SGN 2, SGN2, Signalosome subunit 2, Thyroid Hormone Receptor Interactor15, Thyroid Hormone Receptor Interactor 15, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP 15, TRIP-15.

Background: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

ID gène: 1447

Pathways: Cycle Cellulaire