NFAT5 anticorps (pSer1197)

N° du produit ABIN1387082

L’anticorps Lapin Polyclonal anti-NFAT5 a été validé pour WB, IF (p) et IHC (p). Il convient pour détecter NFAT5 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour NFAT5 anticorps (pSer1197) (ABIN1387082)

Antigène: NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFAT5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-NFAT5 anticorps

Épitope: pSer1197

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human NFAT5 around the phosphorylation site of Ser1197

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur NFAT5

Antigène: NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5))

Autre désignation: NFAT5

Sujet:

Synonyms: NFAT5 phospho S1197, p-NFAT5phospho S1197, Glutamine rich protein H65, KIAA0827, NF AT5, NF-AT5, NFAT 5, NFAT L1, NFAT like protein 1, NFAT5, NFAT5_HUMAN, NFATL 1, NFATL1, NFATZ, Nuclear factor of activated T cells 5, Nuclear factor of activated T cells 5 tonicity responsive, Nuclear factor of activated T cells, Nuclear factor of activated T-cells 5, OREBP, Osmotic response element binding protein, T cell transcription factor NFAT 5, T cell transcription factor NFAT5, T-cell transcription factor NFAT5, TonE binding protein, TonE-binding protein , TonEBP, Tonicity responsive enhancer binding protein, Tonicity-responsive enhancer-binding protein.

Background: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.

ID gène: 10725

Pathways: Signalisation RTK, Signalisation WNT