UBE2N anticorps (AA 56-152) (Biotin)

N° du produit ABIN1398577

Cet anticorps Lapin Polyclonal détecte spécifiquement UBE2N dans ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Rat et Souris.

Aperçu rapide pour UBE2N anticorps (AA 56-152) (Biotin) (ABIN1398577)

Antigène: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBE2N est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-UBE2N anticorps (Biotin)

Épitope: AA 56-152

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Ube2N/UBC13

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur UBE2N

Antigène: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Autre désignation: Ube2N

Sujet:

Synonyms: UBC 13, UBC13, UbCH ben, Ube 2N, Ube2n, UBE2N_HUMAN, ubiquitin carrier protein N, Ubiquitin conjugating enzyme E2 N, Ubiquitin conjugating enzyme E2N homologous to yeast UBC13, Ubiquitin conjugating enzyme E2N UBC13 homolog yeast, Ubiquitin conjugating enzyme E2N, ubiquitin protein ligase N, Ubiquitin-conjugating enzyme E2 N, ubiquitin-conjugating enzyme E2N homologous to yeast UBC13, ubiquitin-conjugating enzyme E2N UBC13 homolog yeast, Ubiquitin-protein ligase N, Yeast UBC13 homolog, bendless like ubiquitin conjugating enzyme, Bendless-like ubiquitin-conjugating enzyme, BLU, EC 6.3.2.19, Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds, MGC131857, MGC8489.

Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBC13, also known as UBE2N or BLU, is a 152 amino acid member of the E2 ubiquitin-conjugating enzyme family. Existing as a heterodimer with Mms2 (also known as UBE2V2), UBC13 catalyzes the ATP-dependent synthesis of non-canonical polyubiquitin chains, a process that does not lead to proteasomal degradation. Additionally, UBC13 mediates the transcription of several target genes and is thought to play a role in cell cycle progression, cellular differentiation and DNA repair mechanisms that ensure cell survival after DNA damage.

ID gène: 7334

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway