ZBTB17 anticorps (AA 331-430) (Cy3)

N° du produit ABIN1407957

Cet anticorps anti-ZBTB17 est un anticorps Lapin Polyclonal détectant ZBTB17 dans WB, IF (cc) et IF (p). Adapté pour Souris.

Aperçu rapide pour ZBTB17 anticorps (AA 331-430) (Cy3) (ABIN1407957)

Antigène: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZBTB17 est conjugé à/à la Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-ZBTB17 anticorps (Cy3)

Épitope: AA 331-430

Réactivité croisée: Souris

Homologie: Human,Rat,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Miz1/ZNF60

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ZBTB17

Antigène: ZBTB17 (Zinc Finger and BTB Domain Containing 17 (ZBTB17))

Autre désignation: Miz1/ZNF60

Sujet:

Synonyms: Miz-1, Myc-interacting zinc finger protein 1, Myc-interacting zinc finger protein, ZBT17, ZBT17_HUMAN, Zbtb17, Zinc finger and BTB domain containing protein 17, Zinc finger and BTB domain-containing protein 17, Zinc finger protein 151, Zinc finger protein 60, ZNF151, ZNF60.

Background: The Myc family, including c-Myc-, N-Myc- and L-Myc, are nuclear proteins with relatively short half lives that contribute an important role in cellular processes such as proliferation, differentiation, apoptosis and transformation. The c-Myc protein activates transcription as part of a heteromeric complex with a number of interacting partners, including Max and Mxi 1, however the transforming properties of the Myc proto-oncogene are believed to be associated with Myc-mediated transcriptional repression. A POZ domain Zn finger protein, designated Miz-1 for Myc-interacting Zn finger protein-1, is a specific target of Myc-induced gene repression. Miz-1 interacts with Myc, but not Max or other Myc partners, and binding of Myc to Miz-1 requires the helix-loop-helix domain of Myc and a short amphipathic helix located in the carboxy-terminus of Miz-1. Miz-1 associates with DNA elements on the adenovirus major late and cyclin D1 promoters and activates transcription of both promoters. Expression of Miz-1 induces potent growth arrest function, and this latency is reversed by the addition of Myc.

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, ER-Nucleus Signaling