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UNC5B anticorps (AA 188-260) (Cy7)

UNC5B Reactivité: Humain, Souris, Rat WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy7
N° du produit ABIN1409478
  • Antigène Voir toutes UNC5B Anticorps
    UNC5B (Netrin receptor UNC5B (UNC5B))
    Épitope
    • 14
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 188-260
    Reactivité
    • 32
    • 23
    • 21
    • 3
    • 3
    Humain, Souris, Rat
    Hôte
    • 27
    • 5
    • 2
    Lapin
    Clonalité
    • 30
    • 4
    Polyclonal
    Conjugué
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UNC5B est conjugé à/à la Cy7
    Application
    • 27
    • 14
    • 12
    • 12
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Dog,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human UNC5B
    Isotype
    IgG
    Top Product
    Discover our top product UNC5B Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    UNC5B (Netrin receptor UNC5B (UNC5B))
    Autre désignation
    UNC5B/UNC5H2 (UNC5B Produits)
    Synonymes
    anticorps unc5h2, anticorps 6330415E02Rik, anticorps A630020F16, anticorps D10Bwg0792e, anticorps Unc5h2, anticorps UNC5H2, anticorps p53RDL1, anticorps UNC5C, anticorps UNC5B, anticorps p53rdl1, anticorps unc-5 netrin receptor B, anticorps unc-5 netrin receptor B L homeolog, anticorps unc5b, anticorps Unc5b, anticorps UNC5B, anticorps unc5b.L
    Sujet

    Synonyms: Netrin receptor UNC5B, Netrin receptor UNC5B Precursor, p53 regulated receptor for death and le, p53 regulated receptor for death and le protein 1, p53-regulated receptor for death and le protein 1, p53RDL1, Protein unc-5 homolog 2, Protein unc-5 homolog B, Protein XUNC 5, Transmembrane receptor Unc5H2, Unc 5 homolog 2, Unc 5 homolog B, UNC 5B, Unc5 C.elegans homolog b, Unc5b, UNC5B_HUMAN, UNC5H2.

    Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. In fact, UNC5H receptors express widely in cells that migrate, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain, but this activity is blocked by the binding of netrin-1. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. Hence, in the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, cartilage, kidney and hematopoietic and immune tissues.

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