CD59 anticorps (FITC)

N° du produit ABIN1449270

Cet anticorps anti-CD59 est un anticorps Souris Monoclonal détectant CD59 dans FACS. Adapté pour Humain.

Aperçu rapide pour CD59 anticorps (FITC) (ABIN1449270)

Antigène: CD59

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD59 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Clone: WK8

Détail du produit anti-CD59 anticorps (FITC)

Specificité: This antibody reacts with human CD59 antigen.

Purification: Protein A agarose

Immunogène: Human myeloma cell line (RPMI8226)

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS containing 1 % BSA and 0.09 % NaN3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8 °C.

Détails sur CD59

Antigène: CD59

Autre désignation: CD59

Sujet: CD59, an 18-20 kDa GPI-anchored glycoprotein, is broadly distributed, present in most tissues, and on all circulating cells. CD59 has been also known as 20 kDa homologous restriction factor (HRF20), membrane attack complex inhibitory factor (MACIF), membrane inhibitor of reactive lysis (MIRL) and protectin. CD59 inhibits the cytolytic activity of complement by binding to C8 and C9 in the assembling of the cytolytic membrane attack complex (MAC), thereby interfering with membrane insertion and pore formation. CD59 and other membrane complement regulatory proteins (CD46 and CD55) are frequently overexpressed on cancer cells, possibly as a mechanism for cancer cells to overcome lysis by complement. CD59 also interacts with T cell-restricted glycoprotein CD2 and plays a role in T cell activation.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin

ID gène: 966

NCBI Accession: NP_000602

UniProt: P13987

Pathways: Système du Complément