CARD10 anticorps (N-Term)

N° du produit ABIN1449965

L’anticorps anti-CARD10 Polyclonal Lapin est utilisé pour la détection de CARD10 dans des échantillons de Humain. Il a été validé pour IHC (p) et EIA.

Aperçu rapide pour CARD10 anticorps (N-Term) (ABIN1449965)

Antigène: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD10 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-CARD10 anticorps

Épitope: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid synthetic peptide near the amino terminus of human CARMA3

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CARD10

Antigène: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Autre désignation: CARD10 / CARMA3

Sujet: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein binds to BCL10 and activates NF-kB Recent experiments have shown that CARMA3 is required for EGF-induced NF-kB activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.Synonyms: BIMP1, CARD10, Caspase recruitment domain family member 10

ID gène: 29775

NCBI Accession: NP_055365

Pathways: S100 Proteins