14-3-3 sigma/SFN anticorps (AA 41-90)

N° du produit ABIN1450896

Cet anticorps anti-14-3-3 sigma/SFN Polyclonal Lapin (ABIN1450896) détecte spécifiquement 14-3-3 sigma/SFN dans WB, IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour 14-3-3 sigma/SFN anticorps (AA 41-90) (ABIN1450896)

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 14-3-3 sigma/SFN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-14-3-3 sigma/SFN anticorps

Épitope: AA 41-90

Fonction: 14-3-3 σ Antibody

Specificité: 14-3-3 σ Polyclonal Antibody detects endogenous levels of 14-3-3 σ protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from human SFN. AA range:41-90

Isotype: IgG

Information d'application

Indications d'application: IHC: 100-300.WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur 14-3-3 sigma/SFN

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Autre désignation: 14-3-3 sigma

Sujet:

Synonyms: SFN, HME1, 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin

Background: function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,

Gene Name: SFN

Protein Name: 14-3-3 protein sigma

Poids moléculaire: 27 kDa

ID gène: 2810

OMIM: 601290

UniProt: P31947

Pathways: Signalisation p53, Myometrial Relaxation and Contraction