MICA anticorps (AA 204-253)

N° du produit ABIN1453404

Cet anticorps anti-MICA Polyclonal Lapin (ABIN1453404) détecte spécifiquement MICA dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MICA anticorps (AA 204-253) (ABIN1453404)

Antigène: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MICA est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-MICA anticorps

Épitope: AA 204-253

Fonction: HLA Class I Antibody

Specificité: The antibody detects endogenous HLA Class I protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from human HLA Class I. AA range:204-253

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000, ELISA 1:10000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur MICA

Antigène: MICA (MHC Class I Polypeptide-Related Sequence A (MICA))

Autre désignation: HLA Class I

Sujet:

Synonyms: HLA-A HLAA

Background: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney trans

Gene Name: HLA-A HLAA

Protein Name: major histocompatibility complex, class I

Poids moléculaire: 40 kDa

OMIM: 142800

UniProt: P04439

Pathways: Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response