TDG anticorps

N° du produit ABIN1526109

Cet anticorps anti-TDG est un anticorps Souris Monoclonal détectant TDG dans WB et EIA. Adapté pour Humain.

Aperçu rapide pour TDG anticorps (ABIN1526109)

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TDG est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT2F7

Détail du produit anti-TDG anticorps

Purification: Protein-A affinity chromatography

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) containing 10 % Glycerol, 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Détails sur TDG

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Autre désignation: TDG

Sujet: G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein. The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.Synonyms: G/T mismatch-specific thymine DNA glycosylase

Pathways: Réparation de l'ADN, Chromatin Binding