TEK anticorps (pTyr1108)

N° du produit ABIN1531402

L’anticorps anti-TEK Polyclonal Lapin est utilisé pour la détection de TEK dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC et ELISA.

Aperçu rapide pour TEK anticorps (pTyr1108) (ABIN1531402)

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TEK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-TEK anticorps

Épitope: AA 1074-1123, pTyr1108

Fonction: Tie-2 (phospho Tyr1108) Antibody

Specificité: Phospho-Tie-2 (Y1108) Polyclonal Antibody detects endogenous levels of Tie-2 protein only when phosphorylated at Y1108.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1108. AA range:1074-1123

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur TEK

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Autre désignation: TIE2

Sujet:

Synonyms: TEK, TIE2, VMCM, VMCM1, Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor

Background: This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014],

Gene Name: TEK

Protein Name: Angiopoietin-1 receptor

Poids moléculaire: 125 kDa

ID gène: 7010

OMIM: 600195

UniProt: Q02763

Pathways: Signalisation RTK, Growth Factor Binding