IRS1 anticorps (pSer307)

N° du produit ABIN1531876

Cet anticorps Lapin Polyclonal détecte spécifiquement IRS1 dans WB, IHC, ELISA et IF. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 1 publication.

Aperçu rapide pour IRS1 anticorps (pSer307) (ABIN1531876)

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-IRS1 anticorps

Épitope: AA 274-323, pSer307

Specificité:

IRS-1 (Phospho-Ser307) Antibody detects endogenous levels of IRS-1 only when phosphorylated at Ser307.

PhosphorylationH:S307 M:S302 R:S302

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human IRS-1 around the phosphorylation site of Ser307.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:10000

Commentaires:

Unigene-Number: Hs.471508 (NCBI Gene Symbol: IRS1)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable at -20°C for at least 1 year.

Date de péremption: 12 months

Références pour anticorps anti-IRS1 (ABIN1531876)

Simon-Szabó, Kokas, Mandl, Kéri, Csala: "Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells." dans: PLoS ONE, Vol. 9, Issue 6, pp. e97868, (2014) (PubMed).

Détails sur IRS1

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Autre désignation: IRS-1

Sujet:

Synonyms: Insulin receptor substrate-1, IRS-1, IRS1

NCBI Gene Symbol: IRS1

Poids moléculaire: 131 kDa

ID gène: 3667

OMIM: 125853

UniProt: P35568

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process