BRCA1 anticorps (AA 1491-1540)

N° du produit ABIN1532821

L’anticorps anti-BRCA1 Polyclonal Lapin est utilisé pour la détection de BRCA1 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, ELISA, IHC (p) et IF (p).

Aperçu rapide pour BRCA1 anticorps (AA 1491-1540) (ABIN1532821)

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-BRCA1 anticorps

Épitope: AA 1491-1540

Fonction: BRCA1 Antibody

Specificité: BRCA1 Polyclonal Antibody detects endogenous levels of BRCA1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human BRCA1. AA range:1491-1540

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur BRCA1

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Autre désignation: BRCA1

Sujet:

Synonyms: BRCA1, RNF53, Breast cancer type 1 susceptibility protein, RING finger protein 53

Background: transforming growth factor beta receptor 3(TGFBR3) Homo sapiens This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010],

Gene Name: BRCA1

Protein Name: Breast cancer type 1 susceptibility protein

Poids moléculaire: 207 kDa

OMIM: 113705

UniProt: P38398

Pathways: Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus