YAP1 anticorps (pSer127)

N° du produit ABIN1536589

Détail du produit anti-YAP1 anticorps

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Épitope: pSer127

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YAP1 est non-conjugé

Application: Dot Blot (DB)

Homologie: X, C, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This YAP Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S127 of human YAP.

Clone: RB35447

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Phospho-YAP-S127 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the Phospho-YAP-S127 Antibody at -20 °C.

Date de péremption: 6 months

Détails sur YAP1

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Autre désignation: YAP (YAP1 Produits)

Synonymes: anticorps YAP, anticorps YAP2, anticorps YAP65, anticorps YKI, anticorps xyap, anticorps yap, anticorps yap2, anticorps yap65, anticorps yki, anticorps AI325207, anticorps Yap, anticorps Yap65, anticorps Yki, anticorps Yorkie, anticorps cb194, anticorps sb:cb194, anticorps si:ch211-181p1.5, anticorps si:dkey-3b8.3, anticorps wu:fc18c04, anticorps zgc:158380, anticorps Yes associated protein 1, anticorps Yes associated protein 1 S homeolog, anticorps yes-associated protein 1, anticorps Yes-associated protein 1, anticorps YAP1, anticorps yap1.S, anticorps Yap1, anticorps yap1

Sujet: Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).

Poids moléculaire: 54462

ID gène: 10413

NCBI Accession: NP_001123617, NP_001181973, NP_001181974, NP_001269027, NP_001269028, NP_001269029, NP_001269030

UniProt: P46937

Pathways: Signalisation MAPK, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha