Lamin A/C anticorps (AA 401-427)

N° du produit ABIN1538393

L’anticorps Lapin Polyclonal anti-Lamin A/C a été validé pour WB. Il convient pour détecter Lamin A/C dans des échantillons de Humain.

Aperçu rapide pour Lamin A/C anticorps (AA 401-427) (ABIN1538393)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB)

Clone: RB21443

Détail du produit anti-Lamin A/C anticorps

Épitope: AA 401-427

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-427 amino acids from the Central region of human LMNA.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: LMNA Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: LMNA

Sujet: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Poids moléculaire: 74139

ID gène: 4000

NCBI Accession: NP_001244303, NP_005563, NP_733821, NP_733822

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus