SNCA anticorps

N° du produit ABIN1580411

L’anticorps anti-SNCA Monoclonal Souris est utilisé pour la détection de SNCA dans des échantillons de Humain et Rongeurs. Il a été validé pour WB, IHC, IF et ICC.

Aperçu rapide pour SNCA anticorps (ABIN1580411)

Antigène: SNCA (Synuclein, alpha (SNCA))

Reactivité: Humain, Rongeurs

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SNCA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 2A7

Détail du produit anti-SNCA anticorps

Purification: affinity purified antibody

Isotype: IgG1

Information d'application

Indications d'application: Try at dilutions of 1:1,000 and higher for immunofluorescence.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4°C short term or -20°C long term.

Détails sur SNCA

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: alpha-Synuclein

Sujet: Alpha synuclein is a member of the synuclein family, the other two proteins being beta and gamma synuclein. Alpha synuclein was originally isolated as a major synaptic vesicle associated protein from the electric organ of the fish Torpedo. Direct homologues of alpha-synuclein are found in all vertebrates. Later work connected alpha-synuclein with human brain pathology, when a protein originally identified as a component of NAC, the Non-Amyloid beta Component of Alzheimer's disease amyloid proved to be a peptide derived from alpha-synuclein. The alpha-synuclein protein is therefore sometimes known as NAC precursor or NACP. Further work showed that alpha-synuclein is a major component of the Lewy bodies of Parkinson's disease and point mutations of alpha-synuclein proved to be causative of some forms of familial Parkinson's disease. However, despite being discovered as as component of amyloid preparations, alpha-synuclein is apparently not a major component of the senile plaques of Alzheimer's disease. Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes. Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS). Alpha-synuclein is heavily expressed in brain and appears to be localized primarily to presynaptic regions, though not with a typical synaptic vesicle distribution pattern. The synuclein proteins appear to have little 3D structure in solution, and probably belong to the family of intrinsically unstructured proteins which only adopt a well-defined conformation when bound to other proteins or membrane lipids. An excellent recent review of the role of alpha-synuclein in health and disease was recently published by Mark Cookson. The HGNC name for this protein is SNCA.

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity