IFIT3 anticorps (AA 128-331)

N° du produit ABIN1680389

L’anticorps anti-IFIT3 Polyclonal Lapin est utilisé pour la détection de IFIT3 dans des échantillons de Souris. Il a été validé pour WB et IHC.

Aperçu rapide pour IFIT3 anticorps (AA 128-331) (ABIN1680389)

Antigène: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFIT3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-IFIT3 anticorps

Épitope: AA 128-331

Séquence: ANPYSMECPE LECEEGWTRL KCGRNERAKM CFEKALEEKP KDPECSSGMA IAMFRLEEKP EKQFSVDALK QAMELNPQNQ YLKVLLALKL LRMGEEAEGE RLIKDALGKA PNQTDVLQKA AQFYKKKGNL DRAIELLGKA LRSTVNNSPL YSLVMCRYRE ILEQLQNKGD ADSSERRQRM AELRRLTMEF MQKTLQRRRS PLNS

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 128-331 of mouse IFIT3 (NP_034631.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000,IHC,1:100 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IFIT3

Antigène: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Autre désignation: IFIT3

Sujet: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.,IFIT3,CIG-49,GARG-49,IFI60,IFIT4,IRG2,ISG60,P60,RIG-G,cig41,Immunology & Inflammation,Cytokines,Interferons,Cell Intrinsic Innate Immunity Signaling Pathway,IFIT3

Poids moléculaire: 47 kDa

ID gène: 15959

UniProt: O14879