Interferon gamma anticorps

N° du produit ABIN1690732

Détail du produit anti-Interferon gamma anticorps

Antigène: Interferon gamma (IFNG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Interferon gamma est non-conjugé

Application: ELISA, Immunoprecipitation (IP), Radioimmunoassay (RIA)

Specificité: The mouse monoclonal antibody NIB42 recognizes IFN-gamma, a 16-25 kDa cytokine produced by activated Th1 cells and NK cells. Binds both glycosylated and non-glycosylated protein.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Recombinant human interferon gamma

Clone: NIB42

Isotype: IgG1 kappa

Information d'application

Indications d'application: ELISA: Capture antibody in combination with detection antibody 4S.B3.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-Interferon gamma (ABIN1690732)

Kofler, Chmielewski, Rappl, Hombach, Riet, Schmidt, Hombach, Wendtner, Abken: "CD28 costimulation Impairs the efficacy of a redirected t-cell antitumor attack in the presence of regulatory t cells which can be overcome by preventing Lck activation." dans: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 19, Issue 4, pp. 760-7, (2011) (PubMed).

Veltkamp, Van Moorsel, Rijkers, Ruven, Van Den Bosch, Grutters: "Toll-like receptor (TLR)-9 genetics and function in sarcoidosis." dans: Clinical and experimental immunology, Vol. 162, Issue 1, pp. 68-74, (2010) (PubMed).

DOmbrain, Robinson, Stanisic, Taraika, Bernard, Michon, Mueller, Schofield: "Association of early interferon-gamma production with immunity to clinical malaria: a longitudinal study among Papua New Guinean children." dans: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 47, Issue 11, pp. 1380-7, (2008) (PubMed).

Joseph, Jones, Kimani, Mwatha, Kamau, Kazibwe, Kemijumbi, Kabatereine, Booth, Kariuki, Ouma, Vennervald, Dunne: "Cytokine production in whole blood cultures from a fishing community in an area of high endemicity for Schistosoma mansoni in Uganda: the differential effect of parasite worm and egg antigens." dans: Infection and immunity, Vol. 72, Issue 2, pp. 728-34, (2004) (PubMed).

Black, Weir, Chaguluka, Warndorff, Crampin, Mwaungulu, Sichali, Floyd, Bliss, Jarman, Donovan, Andersen, Britton, Hewinson, Huygen, Paulsen, Singh, Prestidge, Fine, Dockrell: "Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adults." dans: Clinical and diagnostic laboratory immunology, Vol. 10, Issue 4, pp. 602-11, (2003) (PubMed).

Brattig, Lepping, Timmann, Büttner, Marfo, Hamelmann, Horstmann: "Onchocerca volvulus-exposed persons fail to produce interferon-gamma in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and IL-13 production that decrease with increasing microfilarial density." dans: The Journal of infectious diseases, Vol. 185, Issue 8, pp. 1148-54, (2002) (PubMed).

Détails sur Interferon gamma

Antigène: Interferon gamma (IFNG)

Autre désignation: IFN-gamma (IFNG Produits)

Synonymes: anticorps IFG, anticorps IFI, anticorps IFN-g, anticorps Ifg, anticorps IFNG2, anticorps IFN-gamma, anticorps IFN-G, anticorps IFNG, anticorps IFNgamma, anticorps TCRalpha, anticorps INF-G, anticorps ifng, anticorps interferon gamma, anticorps interferon, gamma 1-2, anticorps IFNG, anticorps Ifng, anticorps ifng1-2

Sujet: Interferon gamma,The interferon gamma (IFN-gamma, 16-25 kDa) is an important regulator of the immune response, produced in activated Th1 cells and NK cells, particularly in response to IL-2, TNF-alpha and IL-12, its production is suppressed by IL-4, IL-10, and TGF-beta. The producing of IFN-gamma is activated by specific antigens or mitogens through the T cell antigen receptor. IFN-gamma polypeptide forms: 40-60 kDa forms are observable under non-denaturing conditions as dimers and trimers, 20 kDa and 25 kDa forms exist due to variable glycosylation. IFN-gamma belongs to the type II interferons, also called immune IFN. IFN-gamma shows antiviral activity and has important immunoregulatory functions. It is a potent activator of macrophages and had antiproliferative effects on transformed cells. IFN-gamma plays an important role in regulating B cell differentiation by simultaneously stimulating class switch recombination to the IgG3 and IgG2a isotypes while represing class switch recombination to the IgE and IgG1 isotypes. It also appears to promote antigen presentation by B cells through its effects on MHC. Binding of IFN-gamma to its receptor increases the expression of class I MHC on all somatic cells. It also enhances the expression of class II MHC on antigen-presenting cells. IFN-gamma is the major means by which T cells activate macrophages, increasing their ability to kill bacteria, parasites, and tumours. The activation of macrophages by IFN-gamma is essential for the elimination of bacteria that replicate within the phagosomes of macrophages (f.e. Mycobacteria and Listeria monocytogenes). IFN-gamma can potentiate the high antiviral and antitumor effects of the type I interferons (IFN-alpha, IFN-beta). IFN-gamma may also activate neutrophils and NK cells.,Interferon gamma, IFN-gamma

ID gène: 3458

UniProt: P01579

Pathways: Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy