C5 anticorps (AbBy Fluor® 350)

N° du produit ABIN1692958

Cet anticorps Lapin Polyclonal détecte spécifiquement C5 dans IF (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour C5 anticorps (AbBy Fluor® 350) (ABIN1692958)

Antigène: C5 (Complement Component 5 (C5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C5 est conjugé à/à la AbBy Fluor® 350

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-C5 anticorps (AbBy Fluor® 350)

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human C5

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at 4°C

Date de péremption: 12 months

Détails sur C5

Antigène: C5 (Complement Component 5 (C5))

Sujet:

The complement component proteins: C2, C3, C4 and C5 are potent anaphyl-atoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. Activation of the complement system leads to the formation of C5b-9 terminal complex, and while C5b-9 can promote cell lysis, the sublytic assembly of C5b-9 on plasma membranes causes an opposite result and induces cell cycle activation and survival. C5b-9 can rescue oligodendrocytes from FAS-mediated apoptosis by regulating caspase-8 processing via PI 3-K signaling. C5b-9 may play a pro-inflammatory role in the acute phase of multiple sclerosis, but may also be neuroprotective during the chronic phase of the disease. Complement C5 precursor contains C5a anaphylatoxin. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis.

Synonyms: Anaphylatoxin C5a analog, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5, C5a, CO5_HUMAN, Complement C5 alpha'' chain, Complement C5, Complement component C5, CPAMD4.

ID gène: 727

Pathways: Système du Complément, Carbohydrate Homeostasis