TSC1 anticorps (AA 701-800) (Biotin)

N° du produit ABIN1700334

Détail du produit anti-TSC1 anticorps (Biotin)

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Épitope: AA 701-800

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSC1 est conjugé à/à la Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Hamartin

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TSC1

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Autre désignation: Hamartin (TSC1 Produits)

Synonymes: anticorps LAM, anticorps TSC, anticorps hamartin, anticorps mKIAA0243, anticorps tsc1, anticorps wu:fc38b04, anticorps fa99f04, anticorps wu:fa99f04, anticorps zgc:63657, anticorps TSC complex subunit 1, anticorps tuberous sclerosis 1, anticorps TSC complex subunit 1b, anticorps TSC complex subunit 1a, anticorps TSC1, anticorps Tsc1, anticorps tsc1b, anticorps tsc1, anticorps tsc1a

Sujet:

Synonyms: Hamartin, kiaa0243, LAM, TSC, TSC1, Tsc1 gene, TSC1_HUMAN, Tuberous sclerosis 1, Tuberous sclerosis 1 protein.

Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas. Two different genetic loci have been linked to TSC, one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin. Tuberin and hamartin interact with each other forming a cystoplasmic complex. Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion. Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney.

ID gène: 7248

Pathways: Signalisation RTK, AMPK Signaling, Regulation of Cell Size, Tube Formation