STAP2 anticorps (AA 151-250) (HRP)

N° du produit ABIN1711091

L’anticorps Lapin Polyclonal anti-STAP2 a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter STAP2 dans des échantillons de Humain.

Aperçu rapide pour STAP2 anticorps (AA 151-250) (HRP) (ABIN1711091)

Antigène: STAP2 (Signal Transducing Adaptor Family Member 2 (STAP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAP2 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-STAP2 anticorps (HRP)

Épitope: AA 151-250

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human STAP2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur STAP2

Antigène: STAP2 (Signal Transducing Adaptor Family Member 2 (STAP2))

Autre désignation: STAP2

Sujet:

Synonyms: BKS, Breast tumor kinase substrate, BRK substrate, Signal transducing adaptor protein 2, Signal-transducing adaptor protein 2, Ssignal transducing adaptor family member 2, STAP 2, STAP-2, STAP2, STAP2_HUMAN.

Background: Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues (1,2). Kinases are capable of influencing the oncogenic potential of cell sytems at the level of oncoprotein or tumor suppressor protein phosphorylation states (1,2). STAP-2 is a protein that contains a pleckstrin homology (PH) domain and an SH2 domain, and associates with BRK (3). BRK (breast tumor kinase, Sik) is a 451 amino acid, nonreceptor protein-tyrosine kinase that is overexpressed in breast tumors and metastatic melanoma cell lines (4). Similar to the Src family of intracellular kinses, BRK is comprised of an SH3 domain, an SH2 domain, and a catalytic domain (5). STAP-2 is susceptiple to tyrosine phosphorylation and may be invovled in tyrosine kinase-mediated signaling cascades, whose aberrant function may lead to metastis (3).

ID gène: 55620

UniProt: Q9UGK3