ABL1 anticorps (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase) (pSer569) (HRP)

Details for Product anti-ABL1 Antibody No. ABIN1712594, Fournisseur: Connectez-vous pour afficher
Antigène
  • ABL
  • JTK7
  • bcr/abl
  • c-ABL
  • p150
  • v-abl
  • AI325092
  • Abl
  • E430008G22Rik
  • c-Abl
  • ABL proto-oncogene 1, non-receptor tyrosine kinase
  • c-abl oncogene 1, non-receptor tyrosine kinase
  • Tyrosine-protein kinase abl-1
  • ABL1
  • Abl1
  • abl-1
  • abl1
Épitope
pSer569
56
47
44
33
31
28
25
16
16
16
16
16
15
15
15
15
15
15
15
14
13
12
11
9
7
7
5
5
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
601
389
310
10
7
1
1
1
1
Hôte
Lapin
603
21
Clonalité
Polyclonal
Conjugué
Cet anticorp ABL1 est conjugé à/à la HRP
31
31
28
16
16
16
15
15
15
15
15
15
15
15
15
15
15
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
355
195
195
165
113
64
44
21
16
11
6
2
2
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Ser569
Isotype IgG
Purification Purified by Protein A.
Autre désignation C-Abl (ABL1 Antibody Extrait)
Sujet

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].

Synonyms: c Ablphospho S569, p-c Ablphospho S569, p-c Ablphospho Ser569, Abelson Murine Leukemia Viral Oncogene Homolog 1, Abelson murine leukemia viral v abl oncogene homolog 1, Abl 1, ABL, Abl protein, Abl1, Bcr/c abl oncogene protein, JTK 7, JTK7, p150 , Proto oncogene tyrosine protein kinase ABL1, Transformation gene oncogene ABL, v abl Abelson murine leukemia viral oncogene homolog 1, v abl, ABL1_HUMAN.

ID gène 25
Pathways Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling
Indications d'application WB 1:100-1000
IHC-P 1:100-500
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Agent conservateur Gentamicin sulfate
Précaution d'utilisation This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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