Complement C4 anticorps (AA 21-120)

N° du produit ABIN1713417

Cet anticorps anti-Complement C4 est un anticorps Lapin Polyclonal détectant Complement C4 dans IF (p), IF (cc), ICC, ELISA, IHC (fro) et IHC (p). Adapté pour Humain.

Aperçu rapide pour Complement C4 anticorps (AA 21-120) (ABIN1713417)

Antigène: Complement C4 (C4) (Complement 4 (C4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Complement C4 est non-conjugé

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Complement C4 anticorps

Épitope: AA 21-120

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Complement C4

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Complement C4

Antigène: Complement C4 (C4) (Complement 4 (C4))

Autre désignation: Complement C4

Sujet:

Synonyms: C4, RG, C4S, CO4, C4A2, C4A3, C4A4, C4A6, C4AD, CPAMD2, CH, C4F, C4B1, C4B2, C4B3, C4B5, C4BD, C4B12, C4B_2, CPAMD3, Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A

Background: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

ID gène: 720, 721

UniProt: P0C0L4

Pathways: Système du Complément