ErbB2/Her2 anticorps (pTyr1222)

N° du produit ABIN1713690

Cet anticorps anti-ErbB2/Her2 est un anticorps Lapin Polyclonal détectant ErbB2/Her2 dans ELISA, IHC (p), IF (p), ICC, IF (cc) et IHC (fro). Adapté pour Humain.

Aperçu rapide pour ErbB2/Her2 anticorps (pTyr1222) (ABIN1713690)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ErbB2/Her2 anticorps

Épitope: pTyr1222

Réactivité croisée: Humain

Homologie: Mouse,Dog,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Tyr1222

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: HER2

Sujet:

Synonyms: ErbB 2 phospho Y1222, p-ErbB 2 phospho Y1222, HER2Tyr1221/Tyr1222,ErbB2, CerbB2, c erb B2, C erbB 2, C-erbB2, CD340, CD340 antigen, Cerb B2/neu protein, Erb B2, erbb2, HER 2, HER 2/neu, HER2, Her2/neu, Herstatin, MLN 19, MLN19, NEU, NEU Proto Oncogene, Neuro Glioblastoma Derived Oncogene Homolog, Neuroblastoma/glioblastoma derived oncogene homolog, NGL, p185 ErbB2, p185erbB2, Receptor Protein Tyrosine Kinase ErbB2 Precursor, Receptor tyrosine protein kinase erbB 2, TKR1, ERBB2_HUMAN.

Background: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

ID gène: 2064

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development