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SOCS5 anticorps (AA 151-250)

SOCS5 Reactivité: Humain WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1713904
  • Antigène Voir toutes SOCS5 Anticorps
    SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))
    Épitope
    • 14
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 151-250
    Reactivité
    • 29
    • 4
    • 2
    Humain
    Hôte
    • 25
    • 3
    • 1
    Lapin
    Clonalité
    • 28
    • 1
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SOCS5 est non-conjugé
    Application
    • 14
    • 12
    • 12
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Homologie
    Human,Mouse,Rat,Cow,Sheep,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SOCS5
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))
    Autre désignation
    SOCS5 (SOCS5 Produits)
    Synonymes
    anticorps SOCS5, anticorps cis6, anticorps cish5, anticorps cish6, anticorps socs-5, anticorps GB18949, anticorps socs5, anticorps zgc:153506, anticorps CIS6, anticorps CISH6, anticorps Cish5, anticorps SOCS-5, anticorps 1810018L08Rik, anticorps mKIAA0671, anticorps RGD1564914, anticorps suppressor of cytokine signaling 5, anticorps suppressor of cytokine signaling 5a, anticorps suppressor of cytokine signaling 5 L homeolog, anticorps SOCS5, anticorps socs5, anticorps LOC552036, anticorps socs5a, anticorps Tsp_07018, anticorps socs5.L, anticorps Socs5
    Sujet

    The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: CIS-6, CIS6, CISH5, CISH6, Cytokine inducible SH2 containing protein 5, Cytokine inducible SH2 protein 6, KIAA0671, SOCS-5, Suppressor of cytokine signaling 5.

    Pathways
    Signalistation JAK/STAT, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process
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