ABL1 anticorps (pTyr115)

N° du produit ABIN1714099

Cet anticorps Lapin Polyclonal détecte spécifiquement ABL1 dans WB, ELISA, IF (cc), IF (p), IHC (p), ICC et IHC (fro). Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour ABL1 anticorps (pTyr115) (ABIN1714099)

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABL1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ABL1 anticorps

Épitope: pTyr115

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Tyr115

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur ABL1

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Autre désignation: c-ABL

Sujet:

Synonyms: c-Ablphospho Y115, c-Ablphospho Tyr115, p-c-AblTyr115, tyrosine-protein kinase ABL1 isoform b, Abelson Murine Leukemia Viral Oncogene Homolog 1, Abelson murine leukemia viral v abl oncogene homolog 1, Abl 1, ABL, Abl protein, Abl1, Bcr/c abl oncogene protein, JTK 7, JTK7, p150 , Proto oncogene tyrosine protein kinase ABL1, Transformation gene oncogene ABL, v abl Abelson murine leukemia viral oncogene homolog 1, v abl, ABL1_HUMAN.

Background: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].

ID gène: 25

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism