SNCA anticorps

N° du produit ABIN1724652

Cité dans 1 publication. Cet anticorps anti-SNCA est un anticorps Monoclonal produit chez le Souris, détectant SNCA dans ELISA et IHC. Convient pour Humain.

Aperçu rapide pour SNCA anticorps (ABIN1724652)

Antigène: SNCA (Synuclein, alpha (SNCA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SNCA est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 2B2D1

Détail du produit anti-SNCA anticorps

Fonction: SNCA Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of SNCA expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-SNCA (ABIN1724652)

Li, Lin, Xie, Hu: "The early events of alpha-synuclein oligomerization revealed by photo-induced cross-linking." dans: Protein and peptide letters, Vol. 13, Issue 4, pp. 385-90, (2006) (PubMed).

Détails sur SNCA

Antigène: SNCA (Synuclein, alpha (SNCA))

Autre désignation: SNCA

Sujet: Alpha-synuclein (SNCA), with 140-amino acid protein (about 15 kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.

ID gène: 6622

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity