GM-CSF anticorps (AA 18-144)

N° du produit ABIN1724740

Cet anticorps Souris Monoclonal détecte spécifiquement GM-CSF dans ELISA. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour GM-CSF anticorps (AA 18-144) (ABIN1724740)

Antigène: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GM-CSF est non-conjugé

Application: ELISA

Clone: 3D3

Détail du produit anti-GM-CSF anticorps

Épitope: AA 18-144

Fonction: CSF2 Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human CSF2 (aa18-144) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-GM-CSF (ABIN1724740)

He, Shumansky, Connett, Anthonisen, Paré, Sandford: "Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD." dans: The European respiratory journal, Vol. 32, Issue 1, pp. 25-34, (2008) (PubMed).

Fuxman Bass, Alvarez, Gabelloni, Vermeulen, Amaral, Geffner, Trevani: "GM-CSF enhances a CpG-independent pathway of neutrophil activation triggered by bacterial DNA." dans: Molecular immunology, Vol. 46, Issue 1, pp. 37-44, (2008) (PubMed).

Hansen, Hercus, McClure, Stomski, Dottore, Powell, Ramshaw, Woodcock, Xu, Guthridge, McKinstry, Lopez, Parker: "The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation." dans: Cell, Vol. 134, Issue 3, pp. 496-507, (2008) (PubMed).

Détails sur GM-CSF

Antigène: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Autre désignation: CSF2

Sujet: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.

Poids moléculaire: 16 kDa

ID gène: 1437

UniProt: P04141

Pathways: Signalistation JAK/STAT, Cellular Response to Molecule of Bacterial Origin