MCAM anticorps (AA 84-189)

N° du produit ABIN1724844

Cet anticorps anti-MCAM est un anticorps Souris Monoclonal détectant MCAM dans FACS, IHC, WB et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour MCAM anticorps (AA 84-189) (ABIN1724844)

Antigène: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MCAM est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Clone: 6C3E6

Détail du produit anti-MCAM anticorps

Épitope: AA 84-189

Fonction: MCAM Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human MCAM (AA: 84-189) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-MCAM (ABIN1724844)

Wang, Yan: "CD146, a multi-functional molecule beyond adhesion." dans: Cancer letters, Vol. 330, Issue 2, pp. 150-62, (2013) (PubMed).

Jouve, Despoix, Espeli, Gauthier, Cypowyj, Fallague, Schiff, Dignat-George, Vély, Leroyer: "The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells." dans: The Journal of biological chemistry, Vol. 288, Issue 4, pp. 2571-9, (2013) (PubMed).

Détails sur MCAM

Antigène: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Autre désignation: MCAM

Sujet: The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Poids moléculaire: 71.6 kDa

ID gène: 4162

UniProt: P43121