CD74 anticorps (AA 1-106)

N° du produit ABIN1724871

Cet anticorps anti-CD74 est un anticorps Souris Monoclonal détectant CD74 dans FACS, WB, ELISA et ICC. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour CD74 anticorps (AA 1-106) (ABIN1724871)

Antigène: CD74 (HLA-DR-gamma (CD74))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD74 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Clone: 2D1B3

Détail du produit anti-CD74 anticorps

Épitope: AA 1-106

Fonction: CD74 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CD74 (AA: 1-106) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CD74 (ABIN1724871)

Tian, Zhang, Li, Liu, Dong: "CD74: a potential novel target for triple-negative breast cancer." dans: Tumour biology, Vol. 33, Issue 6, pp. 2273-7, (2012) (PubMed).

Zheng, Yang, Rong, Yuan, Ma, Wang, Shen, Cui: "CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer." dans: World journal of gastroenterology : WJG, Vol. 18, Issue 18, pp. 2253-61, (2012) (PubMed).

Détails sur CD74

Antigène: CD74 (HLA-DR-gamma (CD74))

Autre désignation: CD74

Sujet: The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: 33.5 kDa

ID gène: 972

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints