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CD11b anticorps (AA 623-728)

Name: CD11b anticorps (AA 623-728)
Brand: antibodies-online
SKU: ABIN1724905
Price: 644.71 EUR
Availability: InStock

ITGAM Reactivité: Humain WB, ELISA, ICC Hôte: Souris Monoclonal 3A10H5 unconjugated

Western blot analysis using ITGAM mAb against human ITGAM recombinant protein. (CD11b anticorps (AA 623-728))

Immunofluorescence analysis of Hela cells using ITGAM mouse mAb (green). (CD11b anticorps (AA 623-728))

Western blot analysis using ITGAM mAb against HEK293 (1) and ITGAM (AA: 623-728)-hIgGFc transfected HEK293 (2) cell lysate. (CD11b anticorps (AA 623-728))

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (CD11b anticorps (AA 623-728))

ELISA

4 images

(2 références)

N° du produit ABIN1724905

Fiche de données

Antigène Voir toutes CD11b (ITGAM) Anticorps

CD11b (ITGAM) (Integrin alpha M (ITGAM))
Épitope
16

14

10

7

6

6

5

5

3

3

3

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 623-728
Reactivité
279

179

70

33

17

17

16

14

11

7

7

5

5

2

2

1
Humain
Hôte
154

114

105

4

1

1
Souris
Anticorps secondaires appropriés
Clonalité
279

96

1
Monoclonal
Conjugué
125

37

32

28

21

11

9

8

8

6

6

6

6

5

4

4

4

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp CD11b est non-conjugé
Application
280

87

79

79

63

44

37

26

24

20

13

13

12

6

5

5

5

4

3

2

2

2

2

2

1

1

1

1

1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification

purified

Immunogène

Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. coli.

Clone

3A10H5

Isotype

IgG1

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Indications d'application

ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C/-20 °C

Stockage commentaire

4°C, -20°C for long term storage
Rhodes, Fürnrohr, Roberts, Tzircotis, Schett, Spector, Vyse: "The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes." dans: Annals of the rheumatic diseases, Vol. 71, Issue 12, pp. 2028-34, (2012) (PubMed).

Grüger, Reiners, Schnitzler, Brandenburg, Zündorf: "Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus." dans: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Vol. 17, Issue 2, pp. 291-6, (2011) (PubMed).
Antigène

CD11b (ITGAM) (Integrin alpha M (ITGAM))

Autre désignation

ITGAM (ITGAM Produits)

Synonymes

anticorps CD11b/CD18, anticorps CR3, anticorps CR3A, anticorps Cd11b, anticorps F730045J24Rik, anticorps Ly-40, anticorps MAC1, anticorps Mac-1, anticorps Mac-1a, anticorps CD11B, anticorps MAC-1, anticorps MAC1A, anticorps MO1A, anticorps SLEB6, anticorps C3bi, anticorps integrin subunit alpha M, anticorps integrin alpha M, anticorps integrin, alpha M (complement component 3 receptor 3 subunit), anticorps integrin alpha-M, anticorps ITGAM, anticorps Itgam, anticorps LOC100351865

Sujet

Description: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. ,
Aliases: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6

Poids moléculaire

127.1 kDa

ID gène

3684

HGNC

3684

Pathways

Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation