CSF1R anticorps (AA 344-497)

N° du produit ABIN1724925

Cet anticorps anti-CSF1R est un anticorps Souris Monoclonal détectant CSF1R dans ELISA, IHC et ICC. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour CSF1R anticorps (AA 344-497) (ABIN1724925)

Antigène: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CSF1R est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: 6B9B9

Détail du produit anti-CSF1R anticorps

Épitope: AA 344-497

Fonction: CSF1R Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CSF1R (AA: 344-497) expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-CSF1R (ABIN1724925)

Morandi, Barbetti, Riverso, Dello Sbarba, Rovida: "The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines." dans: PLoS ONE, Vol. 6, Issue 11, pp. e27450, (2011) (PubMed).

Kitagawa, Gouda, Kirii, Sugiyama, Ishihama, Fujii, Narumi, Akita, Yokota: "Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase." dans: Journal of biochemistry, Vol. 151, Issue 1, pp. 47-55, (2011) (PubMed).

Détails sur CSF1R

Antigène: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Autre désignation: CSF1R

Sujet: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.

Poids moléculaire: 108 kDa

ID gène: 1436

UniProt: P07333

Pathways: Signalisation RTK, Inositol Metabolic Process, Cell-Cell Junction Organization