NRF2 anticorps (AA 356-589)

N° du produit ABIN1724931

Cité dans 1 publication. Cet anticorps anti-NRF2 Monoclonal Souris (Clone 1A6G6) (ABIN1724931) détecte spécifiquement NRF2 dans IHC et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NRF2 anticorps (AA 356-589) (ABIN1724931)

Antigène: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NRF2 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Clone: 1A6G6

Détail du produit anti-NRF2 anticorps

Épitope: AA 356-589

Fonction: NFE2L2 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human NFE2L2 (AA: 356-589) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-NRF2 (ABIN1724931)

Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: "NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease." dans: Physiological genomics, Vol. 44, Issue 15, pp. 754-63, (2012) (PubMed).

Détails sur NRF2

Antigène: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Autre désignation: NFE2L2

Sujet: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters, many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 67.8 kDa

UniProt: Q16236

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling