NRF2 anticorps (pSer40)

N° du produit ABIN676673

Détail du produit anti-NRF2 anticorps

Antigène: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Épitope: pSer40

Reactivité: Humain, Souris, Rat, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NRF2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Porc, Rat

Homologie: Dog,Cow,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human Nrf2 around the phosphorylation site of Ser40 [DF(p-S)QR]

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-NRF2 (ABIN676673)

Ghosh, Abdo, Zhao, Wu, Shi, Lo, Chenier, Alquier, Filep, Ingelfinger, Zhang, Chan: "Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice." dans: Endocrinology, Vol. 158, Issue 4, pp. 903-919, (2017) (PubMed).

Allard, Perez, Fukui, Carpenter, Ingram, de Cabo: "Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice." dans: Behavioural brain research, Vol. 301, pp. 1-9, (2016) (PubMed).

Yen, Chen, Jayakumar, Lu, Hsieh, Hsu, Yang, Chang, Lin, Lin, Sheu et al.: "Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection ..." dans: Translational research : the journal of laboratory and clinical medicine, Vol. 170, pp. 57-72, (2016) (PubMed).

Ko, Rho, Jeon, Kim, Woo, Kim, Kim: "Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-IκB Kinase-NF-κB Pathways in Dendritic Cells." dans: Infection and immunity, Vol. 84, Issue 8, pp. 2162-74, (2016) (PubMed).

Ko, Rho, Jeon, Kim, Woo, Lee, Kim: "Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-κB-Dependent Pathway, Leading to Modulation of Apoptosis." dans: Infection and immunity, Vol. 84, Issue 9, pp. 2541-54, (2016) (PubMed).

Kim, Kim, Jung, Yang, Park, Jun: "EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage." dans: Toxicology and applied pharmacology, Vol. 315, pp. 60-69, (2016) (PubMed).

Cheng, Cheng, Lee, Chung, Chang: "Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo." dans: Nutrients, Vol. 7, Issue 4, pp. 2850-65, (2016) (PubMed).

Chang, Wu, Xu, Liao, Wu, Cheng: "Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation." dans: Molecules (Basel, Switzerland), Vol. 20, Issue 2, pp. 2786-801, (2015) (PubMed).

Kaneko, Takayanagi, Nagasaki, Kodani, Nakashima, Mori, Suzuki, Itoh, Kondo, Nagatsu, Ota, Ota: "Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells." dans: Journal of neural transmission (Vienna, Austria : 1996), Vol. 122, Issue 6, pp. 757-72, (2015) (PubMed).

Santofimia-Castaño, Clea Ruy, Garcia-Sanchez, Jimenez-Blasco, Fernandez-Bermejo, Bolaños, Salido, Gonzalez: "Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca(2+) influx activation in mouse pancreatic acinar cells." dans: Free radical biology & medicine, (2015) (PubMed).

Mo, Wang, Zhang, Numazawa, Tang, Tang, Han, Li, Yang, Wang, Wei, Xiao: "The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice." dans: Antioxidants & redox signaling, Vol. 20, Issue 4, pp. 574-88, (2014) (PubMed).

Kakehashi, Kato, Ishii, Wei, Morimura, Fukushima, Wanibuchi: "Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling." dans: PLoS ONE, Vol. 9, Issue 11, pp. e113610, (2014) (PubMed).

Li, Guo, Xi, Yang, Zhou, Yin, Hai, Li, Qin: "Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways." dans: Oxidative medicine and cellular longevity, Vol. 2014, pp. 320513, (2014) (PubMed).

Patwardhan, Sharma, Checker, Sandur: "Mitigation of radiation-induced hematopoietic injury via regulation of cellular MAPK/phosphatase levels and increasing hematopoietic stem cells." dans: Free radical biology & medicine, Vol. 68, pp. 52-64, (2014) (PubMed).

Lee, Hsu, Hsu, Pan: "Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid." dans: Free radical biology & medicine, Vol. 60, pp. 7-16, (2013) (PubMed).

Hsu, Lee, Li, Hsu, Pan: "Monascin and AITC attenuate methylglyoxal-induced PPAR? phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation." dans: Journal of agricultural and food chemistry, Vol. 61, Issue 25, pp. 5996-6006, (2013) (PubMed).

Lee, Lee, Cheng, Chang, Hsu, Wu: "Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 62, pp. 492-8, (2013) (PubMed).

Lee, Hsu, Chang, Kuo, Hsu, Pan: "Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo." dans: Free radical biology & medicine, Vol. 53, Issue 11, pp. 2008-16, (2012) (PubMed).

Détails sur NRF2

Antigène: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Autre désignation: Nrf2 (NFE2L2 Produits)

Synonymes: anticorps Nrf2, anticorps nfe2l2, anticorps wu:fc15g09, anticorps wu:fj67e03, anticorps NF-E2R2, anticorps NRF2, anticorps AI194320, anticorps nuclear factor, erythroid 2-like 2a, anticorps nuclear factor, erythroid 2 like 2 S homeolog, anticorps nuclear factor, erythroid 2 like 2, anticorps nuclear factor, erythroid derived 2, like 2, anticorps nuclear factor, erythroid 2-like 2, anticorps nfe2l2a, anticorps nfe2l2.S, anticorps NFE2L2, anticorps Nfe2l2

Sujet:

Synonyms: NRF2, Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor, erythroid derived 2, like 2, NFE2L2

Background: Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

ID gène: 4780

UniProt: Q16236

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling