Metabotropic Glutamate Receptor 1 anticorps (AA 1159-1171)

N° du produit ABIN1736899

Cet anticorps Lapin Polyclonal détecte spécifiquement Metabotropic Glutamate Receptor 1 dans WB et IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour Metabotropic Glutamate Receptor 1 anticorps (AA 1159-1171) (ABIN1736899)

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Metabotropic Glutamate Receptor 1 anticorps

Épitope: AA 1159-1171

Specificité: Reacts with GluR1 protein form human, mouse and rat

Purification: Antigen affinity purified

Immunogène: Synthetic peptide comprising residues 1159-1171 [SSVPSSPVSESVL] of the human GluR1 protein.

Isotype: IgG

Information d'application

Indications d'application:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
- IHC : 1/100 to 1/500 - WB : 1/500 to 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, Sodium azide 0.02 %

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Date de péremption: 6 months

Détails sur Metabotropic Glutamate Receptor 1

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Autre désignation: Metabotropic Glutamate Receptor 1a (mGluR1)

Sujet: The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors.Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C.Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined.Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.mGluR1 has been reported in various regions of the brain and spinal cord.ESTs have been isolated from brain and eye libraries.Caution:GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).