Metabotropic Glutamate Receptor 1 anticorps

N° du produit ABIN7190883

Détail du produit anti-Metabotropic Glutamate Receptor 1 anticorps

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris, Rat

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of Human GRM1

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:15-1:50,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Metabotropic Glutamate Receptor 1

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Autre désignation: GRM1 (GRM1 Produits)

Synonymes: anticorps fj39d05, anticorps wu:fj39d05, anticorps si:ch211-51a19.1, anticorps Glura, anticorps mGlutR, anticorps GB18621, anticorps GPRC1A, anticorps MGLU1, anticorps MGLUR1, anticorps SCAR13, anticorps 4930455H15Rik, anticorps ENSMUSG00000075319, anticorps Gm10828, anticorps Gprc1a, anticorps mGluR1, anticorps nmf373, anticorps rcw, anticorps wobl, anticorps glutamate metabotropic receptor 1, anticorps glutamate receptor, metabotropic 1a, anticorps metabotropic glutamate receptor 1, anticorps glutamate receptor, metabotropic 1, anticorps GRM1, anticorps grm1a, anticorps mGlutR1, anticorps Grm1

Sujet:

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms, some of which may have distinct functions.

Aliases: Glutamate receptor metabotropic 1 antibody, glutamate receptor, metabotropic 1 antibody, GPRC1A antibody, GRM1 antibody, GRM1-Alpha antibody, GRM1_HUMAN antibody, GRM1A antibody, Metabotropic glutamate receptor 1 antibody, mGlu1 antibody, mGluR1 antibody, MGLUR1-Alpha antibody, MGLUR1A antibody, SCAR13 antibody

UniProt: Q13255