FcRn anticorps

N° du produit ABIN1774763

L’anticorps Souris Monoclonal anti-FcRn a été validé pour ELISA, IF, FACS et cELISA. Il convient pour détecter FcRn dans des échantillons de Humain. Il y a 6+ publications disponibles.

Aperçu rapide pour FcRn anticorps (ABIN1774763)

Antigène: FcRn (neonatal Fc Receptor (FcRn))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FcRn est non-conjugé

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA)

Clone: DVN24

Détail du produit anti-FcRn anticorps

Highlights:

• Anticorps FcRn de haute qualité (Clone DVN24) pour la détection de FcRn.
• Hautement spécifique du FcRn humain, bloque la liaison de l'IgG.
• PBS-only, preservative free.
• 2 références PubMed disponibles pour cet anticorps FcRn.

Attributs du produit: based on recognition of the complete native protein expressed on transfected mammalian cells

Purification: Purified, Protein G

Immunogène: hFcRn

Isotype: IgG2a kappa

Informations sur le produit:

Limited uses of our FcRn antibody ABIN1774763 / DVN24

Information d'application

Indications d'application: Flow cytometry: 1.2 μg/10^6 cells ELISA: 1:200 - 1:400CELISA: 1:200 - 1:400For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Stockage

Buffer: PBS pH 7.2

Conseil sur la manipulation: avoid repeated freezing and thawing

Stock: 4 °C

Références pour anticorps anti-FcRn (ABIN1774763)

Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." dans: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).

Hubbard, Pyzik, Rath, Kozicky, Sand, Gandhi, Grevys, Foss, Menzies, Glickman, Fiebiger, Roopenian, Sandlie, Andersen, Sly, Baker, Blumberg: "FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity." dans: The Journal of experimental medicine, Vol. 217, Issue 10, (2021) (PubMed).

Cines, Zaitsev, Rauova, Rux, Stepanova, Krishnaswamy, Sarkar, Kowalska, Zhao, Mast, Blumberg, McCrae, Poncz, Hubbard, Pyzik, Blumberg: "FcRn augments induction of tissue factor activity by IgG-containing immune complexes." dans: Blood, Vol. 135, Issue 23, pp. 2085-2093, (2021) (PubMed).

Grevys, Nilsen, Sand, Daba, Øynebråten, Bern, McAdam, Foss, Schlothauer, Michaelsen, Christianson, Roopenian, Blumberg, Sandlie, Andersen: "A human endothelial cell-based recycling assay for screening of FcRn targeted molecules." dans: Nature communications, Vol. 9, Issue 1, pp. 621, (2018) (PubMed).

Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." dans: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).

Sand, Dalhus, Christianson, Bern, Foss, Cameron, Sleep, Bjørås, Roopenian, Sandlie, Andersen: "Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies." dans: The Journal of biological chemistry, Vol. 289, Issue 24, pp. 17228-39, (2014) (PubMed).

Détails sur FcRn

Antigène: FcRn (neonatal Fc Receptor (FcRn))

Sujet: The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process