NGFR anticorps (N-Term)

N° du produit ABIN180341

Détail du produit anti-NGFR anticorps

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Épitope: AA 1-160, N-Term

Reactivité: Humain, Lapin, Cat, Furet, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NGFR est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Specificité: This antibody recognizes CD271/NGFR, a transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within amino acids 1-160.
Cellular Localization: Cell Surface, Cytoplasmic.

Réactivité croisée (Details): Species reactivity (tested):Human, Monkey (Cebus apella, Macaca fascicularis, mulatta, and nemestrina), Baboon (Papio anubis and Cynocephalus), Cat, Rabbit, and Ferret.

Attributs du produit: Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16

Purification: Protein-A affinity chromatography

Immunogène: NGFR (75kD) from A875 Melanoma Cells.

Clone: NGFR5

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry. Immunocytochemistry. Inhibits Binding of NGF to Melanoma Cells (see Ref.1, use antibody without azide: ABIN180340). Not suitable for Western Blotting andImmunohistochemistry. Recommended Positive Control: Melanoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.4, 15 mM Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2-8 °C for up to one month or in aliquots at -20 °C for longer. Avoid repeated freezethaw cycles!
Shelf life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-NGFR (ABIN180341)

Molina-Ruiz, Cerroni, Kutzner, Requena: "Immunohistochemistry in the diagnosis of cutaneous bacterial infections." dans: The American Journal of dermatopathology, Vol. 37, Issue 3, pp. 179-93; quiz 194-6, (2015) (PubMed).

Alpers, Hudkins, Ferguson, Johnson, Schatteman, Bothwell: "Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 69, Issue 6, pp. 703-13, (1994) (PubMed).

Schatteman, Gibbs, Lanahan, Claude, Bothwell: "Expression of NGF receptor in the developing and adult primate central nervous system." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 8, Issue 3, pp. 860-73, (1988) (PubMed).

Marano, Dietzschold, Earley, Schatteman, Thompson, Grob, Ross, Bothwell, Atkinson, Koprowski: "Purification and amino terminal sequencing of human melanoma nerve growth factor receptor." dans: Journal of neurochemistry, Vol. 48, Issue 1, pp. 225-32, (1987) (PubMed).

Détails sur NGFR

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Autre désignation: CD271 / NGFR (NGFR Produits)

Synonymes: anticorps ngfr, anticorps wu:fb38c02, anticorps wu:fc10h01, anticorps CD271, anticorps Gp80-LNGFR, anticorps TNFRSF16, anticorps p75(NTR), anticorps p75NTR, anticorps LNGFR, anticorps RNNGFRR, anticorps Tnfrsf16, anticorps p75, anticorps NRH1b, anticorps fullback, anticorps nrh1, anticorps p75ntr, anticorps tnfrsf16, anticorps p75NGFR, anticorps nerve growth factor receptor, anticorps neurotrophin receptor associated death domain, anticorps nerve growth factor receptor S homeolog, anticorps nerve growth factor receptor (TNFR superfamily, member 16), anticorps NGFR, anticorps nradd, anticorps Ngfr, anticorps ngfr.S

Sujet: CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16

Poids moléculaire: 75 kDa

ID gène: 4804

UniProt: P08138

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding