Clusterin anticorps

N° du produit ABIN181112

L’anticorps Souris Monoclonal anti-Clusterin a été validé pour WB, FACS, EIA et IHC (fro). Il convient pour détecter Clusterin dans des échantillons de Humain.

Aperçu rapide pour Clusterin anticorps (ABIN181112)

Antigène: Clusterin (CLU)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Clusterin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 3R3-2

Détail du produit anti-Clusterin anticorps

Specificité: This antibody recognises clusterin, an ubiquitously expressed protein of two 40- kDa chains, alpha and beta, covalently joined by disulfide bonds.

Attributs du produit: Synonyms: Clusterin, APOJ, CLI, KUB1, AAG4, NA1/NA2, SP-40, 40, Complement-associated proteinSP-40, Complement cytolysis inhibitor, Testosterone-repressed prostate message 2,Ku70-binding protein 1, Aging-associated gene 4 protein

Purification: Affinity chromatography on Protein A

Immunogène: Glomerular basement membrane from a post-mortem kidney.

Isotype: IgG1

Information d'application

Indications d'application: ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptocial glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Clusterin

Antigène: Clusterin (CLU)

Autre désignation: Apolipoprotein J (Apo J)

Sujet: Clusterin exists in two forms, a pro-apoptotic form localised to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimers disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2

ID gène: 1191

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling