Complement Factor H anticorps

N° du produit ABIN181114

Cet anticorps Souris Monoclonal détecte spécifiquement Complement Factor H dans WB, FACS, EIA et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour Complement Factor H anticorps (ABIN181114)

Antigène: Complement Factor H (CFH)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Complement Factor H est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 10-10-14

Détail du produit anti-Complement Factor H anticorps

Specificité: This antibody recognises Complement Factor H which exists in 2 forms.

Attributs du produit: Synonyms: CFH, HF, HF1, HF2, H factor 1

Purification: Affinity Chromatography on Protein A.

Immunogène: Purified human factor H from serum.

Isotype: IgG1

Information d'application

Indications d'application: ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Complement Factor H

Antigène: Complement Factor H (CFH)

Sujet: Complement factor H exists in 2 forms, the most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.Synonyms: CFH, H factor 1, HF, HF1, HF2

ID gène: 3075

UniProt: P08603

Pathways: Système du Complément, Cellular Response to Molecule of Bacterial Origin