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IGFBP5 anticorps

IGFBP5 Reactivité: Humain WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN181656
  • Antigène Voir toutes IGFBP5 Anticorps
    IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))
    Reactivité
    • 48
    • 32
    • 13
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 50
    • 11
    • 3
    • 1
    Lapin
    Clonalité
    • 52
    • 13
    Polyclonal
    Conjugué
    • 31
    • 13
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IGFBP5 est non-conjugé
    Application
    • 61
    • 20
    • 19
    • 13
    • 13
    • 8
    • 6
    • 5
    • 4
    • 4
    • 4
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects Insulin-like Growth Factor Binding Protein 5.
    Purification
    Immunoaffinity Chromatography
    Immunogène
    Highly pure (> 98 %) recombinant human IGF-BP5
    Top Product
    Discover our top product IGFBP5 Anticorps primaire
  • Indications d'application
    Indirect ELISA: To detect hIGF-BP5 (using 100 μL/well antibody solution) a concentration of0.5-2.0 μg/mL of this antibody is required. In conjunction with compatible secondaryreagents, it allows the detection of at least 0.2-0.4 ng/well of recombinant hIGF-BP5. Sandwich ELISA: To detect hIGF-BP5 (using 100 μL/well antibody solution) a concentrationof 0.5-2.0 μg/mL of this antibody is required. In conjunction with Biotinylated Anti-HumanIGF-BP5 (ABIN181653 or ABIN181654) as a detection antibody, it allows the detection ofat least 0.2-0.4 ng/well of recombinant hIGF-BP5. Western blot: To detect hIGF-BP5 this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit forrecombinant hIGF-BP5 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
    Buffer
    PBS, pH 7.2
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the lyophilized antibody at -20 °C. Following reconstitution it is stable for two weeks at 2-8 °C. Frozen aliquots are stable for 6 months when stored at -20 °C.
    Date de péremption
    6 months
  • Antigène
    IGFBP5 (Insulin-Like Growth Factor Binding Protein 5 (IGFBP5))
    Autre désignation
    IGFBP5 (IGFBP5 Produits)
    Synonymes
    anticorps IBP5, anticorps AI256729, anticorps AW208790, anticorps IGFBP-5, anticorps IGFBP-5P, anticorps IGF-BP5, anticorps igfbp5, anticorps ibp5, anticorps IBP-5, anticorps xIGFBP-5, anticorps IGFBP5, anticorps igfbp5b, anticorps zgc:165472, anticorps insulin like growth factor binding protein 5, anticorps insulin-like growth factor binding protein 5, anticorps insulin like growth factor binding protein 5 L homeolog, anticorps insulin-like growth factor binding protein 5b, anticorps insulin-like growth factor-binding protein 5, anticorps insulin-like growth factor binding protein 5a, anticorps IGFBP5, anticorps Igfbp5, anticorps igfbp5.L, anticorps igfbp5b, anticorps igfbp5, anticorps LOC100194500, anticorps igfbp5a
    Sujet
    IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.Synonyms: IBP-5, IBP5, IGF-binding protein 5, IGFBP-5, Insulin-like growth factor-binding protein 5
    ID gène
    3488
    NCBI Accession
    NP_000590
    UniProt
    P24593
    Pathways
    Signalisation WNT, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
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