PRKAA1 anticorps (N-Term)

N° du produit ABIN1819880

L’anticorps anti-PRKAA1 Monoclonal Souris est utilisé pour la détection de PRKAA1 dans des échantillons de Humain, Souris, Rat, Drosophila melanogaster et Vertebrate. Il a été validé pour WB, IHC, ELISA, IF, IP et IHC (fro).

Aperçu rapide pour PRKAA1 anticorps (N-Term) (ABIN1819880)

Antigène: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Reactivité: Humain, Souris, Rat, Drosophila melanogaster, Vertebrate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRKAA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 34-2

Détail du produit anti-PRKAA1 anticorps

Épitope: N-Term

Specificité: Recognizes both the alpha 1 and the alpha 2 isoforms of AMP-activated protein kinase (AMPK). AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilized by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels. AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. Recent studies suggest that AMPK functions as a suppressor of cell proliferation of both malignant and normal cells.

Purification: Protein G purified

Immunogène: 29 amino acid peptide within the N-terminal catalytic domain of Drosophila AMPK alpha.

Isotype: IgG2a

Information d'application

Indications d'application: Approved: ELISA, IF, IHC, IHC-Fr, IP, WB (1:100 - 1:1000)

Commentaires:

Target Species of Antibody: Drosophila

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: 4°C or -20°C, Avoid freeze-thaw cycles.

Détails sur PRKAA1

Antigène: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Autre désignation: PRKAA1 / AMPK Alpha 1

Sujet: Name/Gene ID: PRKAA1
Subfamily: AMPK/SNF1
Family: Protein Kinase

Synonyms: PRKAA1, ACACA kinase, AMPK alpha 1, AMPK alpha-1 chain, Acetyl-CoA carboxylase kinase, AMPKa1, AMPK subunit alpha-1, AMPK, AMPK1, Tau-protein kinase PRKAA1, HMGCR kinase

ID gène: 5562

UniProt: Q13131

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg