JUP anticorps

N° du produit ABIN187369

Cet anticorps Souris Monoclonal détecte spécifiquement JUP dans WB, IF et IP. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour JUP anticorps (ABIN187369)

Antigène: JUP (Junction Plakoglobin (JUP))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JUP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 15F11

Détail du produit anti-JUP anticorps

Specificité: Reacts with human plakoglobin. Cross-reacts with rat and weakly cross-reacts with mouse plakoglobin. Species Reactivity: Human, mouse and rat. Others not tested.

Stérilité: 0.2 μm filtered

Isotype: IgG1

Information d'application

Indications d'application: Immunofluorescence: (cells fixed in paraformaldehyde) Use at a 1:10 dilution Immunoprecipitation Western blot: Use at a 1:10 dilution The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS containing 0.1% protein stabilizer.

Stock: 4 °C

Détails sur JUP

Antigène: JUP (Junction Plakoglobin (JUP))

Autre désignation: Junction plakoglobin

Sujet: Plakoglobin belongs together with alpha- and beta-catenin to the catenin family. Catenins mediate cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoblobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas.

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location