JUP anticorps

N° du produit ABIN187369

Détail du produit anti-JUP anticorps

Antigène: JUP (Junction Plakoglobin (JUP))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp JUP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Specificité: Reacts with human plakoglobin. Cross-reacts with rat and weakly cross-reacts with mouse plakoglobin. Species Reactivity: Human, mouse and rat. Others not tested.

Stérilité: 0.2 μm filtered

Clone: 15F11

Isotype: IgG1

Information d'application

Indications d'application: Immunofluorescence: (cells fixed in paraformaldehyde) Use at a 1:10 dilution Immunoprecipitation Western blot: Use at a 1:10 dilution The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS containing 0.1% protein stabilizer.

Stock: 4 °C

Détails sur JUP

Antigène: JUP (Junction Plakoglobin (JUP))

Autre désignation: Junction plakoglobin (JUP Produits)

Synonymes: anticorps ARVD12, anticorps CTNNG, anticorps DP3, anticorps DPIII, anticorps PDGB, anticorps PKGB, anticorps arvd12, anticorps ctnng, anticorps dp3, anticorps dpiii, anticorps pdgb, anticorps pkgb, anticorps plak, anticorps D930025P04Rik, anticorps PG, anticorps cb80, anticorps danPG, anticorps fb11b06, anticorps jup, anticorps wu:fb11b06, anticorps junction plakoglobin, anticorps junction plakoglobin L homeolog, anticorps Junction plakoglobin, anticorps junction plakoglobin a, anticorps junction plakoglobin S homeolog, anticorps JUP, anticorps Jup, anticorps jup, anticorps jup.L, anticorps Tsp_06656, anticorps plak, anticorps jupa, anticorps jup.S

Sujet: Plakoglobin belongs together with alpha- and beta-catenin to the catenin family. Catenins mediate cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoblobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas.

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location