Caspase 7 anticorps (N-Term)

N° du produit ABIN187518

Cet anticorps anti-Caspase 7 est un anticorps Souris Monoclonal détectant Caspase 7 dans WB. Adapté pour Humain.

Aperçu rapide pour Caspase 7 anticorps (N-Term) (ABIN187518)

Antigène: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 7 est non-conjugé

Application: Western Blotting (WB)

Clone: MCH3-14

Détail du produit anti-Caspase 7 anticorps

Épitope: N-Term

Stérilité: 0.2 μm filtered

Immunogène: Synthetic peptide corresponding to amino acids 1 to 11 of the human caspase-7 enzyme.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Mouse monoclonal antibody against human Caspase-7 (cysteine-requiring aspartate protease-7). Available in 100 ul vials at a concentration of 1 mg/ml (100ug) in PBS with 0.08% sodium azide. The antibody is 0.2 um sterile filtered.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Caspase 7

Antigène: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Autre désignation: Caspase-7

Sujet: Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha lodrin, NuMa and others. Caspase-7 is a 303 amino acid protein with high similarity to caspase-3. Caspase-7 is found in three variant forms. Granzyme B activates pro-caspase-7 to a form which can cleave PARP to its key fragment of about 85 kDa. Also, in vivo caspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7 has been shown to exist as dimers or high order oligomers. Caspase-7 may be an important intracellular effector of granzyme B-medicated apoptosis and cytotoxic T-lymphocyte-induced cell killing in vivo.

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity